Neurostimulation as a Putative Method for Treatment of Drug-Resistant Epilepsy in Patient and Animal Models of Epilepsy

Authors

  • Azam Sadeghin Researcher Tarbiat Modares University, Department of Physiology, Tehran, Iran.
  • Meysam Zare Researcher Stem cell and Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran.
  • Nooshin Ahmadirad Associate Research Scientist Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
  • Samaneh Dehghan Eye Research Center, the Five Senses Institute, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
  • Zahra Ghasemi Associate Research Scientist - Lunenfeld-Tanenbaum Research Institute, Toronto, Canada
Abstract:

A patient with epilepsy was shown to have neurobiological, psychological, cognitive, and social issues as a result of recurring seizures, which is regarded to be a chronic brain disease.However, despite numerous drug treatments, approximately, 30–40% of all patients are resistant to antiepileptic drugs. Therefore, newer therapeutic modalities are introduced into clinical practice in which involve neurostimulation and direct stimulation of the brain. Hence, we review published literature regarding the vagus nerve stimulation, trigeminal nerve stimulation, applying responsive stimulation systems and DBS in animals and epileptic patient with an emphasis on drug-resistant epilepsy.

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volume 14  issue 1

pages  0- 0

publication date 2023-01

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